Simply put: I teared through most of the game running two partial set bonuses using the following gear:
Head and Body can be exchanged for more power - but look less appealing.
My weapon of choice:
Implants can vary quite a bit. The following helped:
This build is based on Impact. Very high impact. Against regular enemies there is no need to back up or block. Once in a while dodging can be useful but anyone hit by the hammer will be staggered, crushed to the floor or flying around anyway. Only few enemies will survive a combo. While the Cellular Regenerator is running you can basically tank through anything. If things get harder you can throw in a Medi-Voltaic Injection to heal up quickly. Electric stuns combined with multiple enemies can be a little more demanding in late game but nothing to worry about.
All Bosses work basically the same way. Dodge their attacks, jump in, hit once or twice and back up. Repeat. Getting a full combo off is pretty much impossible. Charging attacks and just eating the damage might actually work against some of them but I haven't tried that on all of them as you sometimes get knocked away.
Another build that works fairly well in normal game and NG+.
Weapons:
This build also works well with Punching Gloves.
Implants:
This is basically a single target annihilation build. Periodic stuns combined with raw attack speed will melt enemies in split seconds. I like that build a lot but against multiple targets and bosses I prefer to fall back on my hammer build once in a while because of its raw power.
This is the build I currently use for farming Techscrap and body parts in NG++.
Implants: